RESEARCH
The long-term goal of our research program is to decipher the underlying mechanisms of global transcriptional and epigenetic regulations in early embryo development, especially by using embryonic stem (ES) and trophoblast stem (TS) cells as model systems. We are also interested in regulatory factors balancing stem cell differentiation and programmed cell death. CpG island-dependent global gene regulatory mechanisms in various cellular contexts is another topic we have studied.